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Effective therapeutic control of curve progression using calcium and vitamin D supplementation for adolescent idiopathic scoliosis – a randomized double-blinded placebo-controlled trial

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Bone Abstracts (2017) 6 OC8 | DOI: 10.1530/boneabs.6.OC8
Objectives: Adolescent Idiopathic Scoliosis (AIS) is associated with low bone mass. This study aimed at evaluating the therapeutic effect and its determinants of Ca+Vit-D supplementation in improving bone strength and preventing curve progression in AIS.

Methods: This was a randomized double-blinded placebo-controlled trial recruiting AIS girls (11–14 years old, Tanner stage50 nmol/l (N=29), no difference on curve progression was noted. For those with baseline dietary calcium intake ≤1000 mg/day (N=109), 19.0% progressed in Group 3 as compared with 54.3% in Group 1 (P=0.001). For those with calcium intake>1000 mg/day (N=23), no difference on curve progression was noted.

Table 1 Mean changes on serum 25(OH)Vit-D level and Finite Element Analysis (FEA) parameters at 2-year for Group 1, 2 and 3.

Conclusion: The results of this study provide strong evidences that calcium+Vit-D supplementation can improve bone strength in AIS. Its therapeutic effect on preventing curve progression is correlated with increase in FEA parameters, low baseline 25(OH)Vit-D level and low baseline dietary calcium intake.

Funding Source Pfizer Inc (IIRGrant:WI174540). (ClinicalTrials.gov-Identifier: NCT01103115).

Disclosure: The authors declared no competing interests.