Bone Abstracts (2017) 6 OC8 | DOI: 10.1530/boneabs.6.OC8
Objectives: Adolescent Idiopathic Scoliosis (AIS) is associated with low bone mass. This study aimed at evaluating the therapeutic effect and its determinants of Ca+Vit-D supplementation in improving bone strength and preventing curve progression in AIS.
Methods: This was a randomized double-blinded placebo-controlled trial recruiting AIS girls (11–14 years old, Tanner stage
Table 1 Mean changes on serum 25(OH)Vit-D level and Finite Element Analysis (FEA) parameters at 2-year for Group 1, 2 and 3.
Conclusion: The results of this study provide strong evidences that calcium+Vit-D supplementation can improve bone strength in AIS. Its therapeutic effect on preventing curve progression is correlated with increase in FEA parameters, low baseline 25(OH)Vit-D level and low baseline dietary calcium intake.
Funding Source Pfizer Inc (IIRGrant:WI174540). (ClinicalTrials.gov-Identifier: NCT01103115).
Disclosure: The authors declared no competing interests.